What is Diabetes?

Insulin

Insulin Resistance

Diabetes Market

Diabetes



Insulin Resistance:

Insulin resistance is a condition in which body cells become less sensitive to the glucose-lowering effects of the hormone insulin. In most cases in humans, normal blood levels of insulin become inadequate to keep blood glucose within a normal range.

Insulin resistance in muscle and fat cells reduces glucose uptake whereas insulin resistance in liver cells results in reduced glycogen synthesis and storage and a failure to suppress glucose production and release into the blood. Insulin resistance normally refers to reduced glucose-lowering effects of insulin. However, other functions of insulin can also be affected. Insulin resistance in fat cells reduces the normal effects of insulin on lipids and results in reduced uptake of circulating lipids and increased hydrolysis of stored triglycerides.

Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Elevated blood fatty-acid concentrations, reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. If insulin resistance exists, more insulin needs to be secreted by the pancreas. If this compensatory increase does not occur, blood glucose concentrations increase and Type II diabetes occurs.


Home  |  Company  |  Diabetes  |  Sucanon  |  Investor Relations  |  Contact  |  Legal Disclaimer  |  Privacy Policy